Introduction: More applications

Pick and place – FluidFM has been used as cell sorter for mammalian cells as for example described in Guillaume-Gentil et al. (Guillaume-Gentil, O., Zambelli, T. & Vorholt, J. A. Isolation of single mammalian cells from adherent cultures by fluidic force microscopy. Lab. Chip 14, 402 (2014). DOI: 10.1039/C3LC51174J).

Single cell injection- FluidFM has been used to transfect mammalian cells in the nucleus by force controlled entering with the cantilever tip and delivering the liquid wished to be injected (for example Guillaume-Gentil, O. et al. Force-Controlled Fluidic Injection into Single Cell Nuclei. Small 9, 1904–1907 (2013)).

Electrospray – Liquid was deposited with high voltage without contacting the surface with FluidFM cantilevers contacted by a back electrode (Geerlings, J. et al. Electrospray deposition from AFM probes with nanoscale apertures. in 2014 IEEE 27th Int. Conf. Micro Electro Mech. Syst. MEMS 100–103 (2014). doi:10.1109/MEMSYS.2014.6765583)

Renewable mercury electrode – By filling the FluidFM cantilever with mercury a renewable liquid electrode was generated in this proof of principle study (Schön, P., Geerlings, J., Tas, N. & Sarajlic, E. AFM Cantilever with in Situ Renewable Mercury Microelectrode. Anal. Chem. 85, 8937–8942 (2013)). 

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